| | Advertisement | | | | | | | | | | Latest Articles | View all Articles | | | Zika virus infection in pregnant rhesus macaques causes placental dysfunction and immunopathology OPEN | | Alec J. Hirsch, Victoria H. J. Roberts, Peta L. Grigsby, Nicole Haese, Matthias C. Schabel, Xiaojie Wang, Jamie O. Lo, Zheng Liu, Christopher D. Kroenke, Jessica L. Smith, Meredith Kelleher, Rebecca Broeckel, Craig N. Kreklywich, Christopher J. Parkins, Michael Denton, Patricia Smith, Victor DeFilippis, William Messer, Jay A. Nelson, Jon D. Hennebold et al. | | | Zika virus infection during pregnancy can result in birth defects, but underlying pathogenesis at the maternal-fetal interface is unclear. Here, the authors use non-invasive in vivo imaging of Zika-infected rhesus macaques and show that infection results in abnormal oxygen transport across the placenta. | | 17 January 2018 | doi: 10.1038/s41467-017-02499-9 | | Disease model Magnetic resonance imaging Ultrasonography Viral pathogenesis | Full-field thermal imaging of quasiballistic crosstalk reduction in nanoscale devices OPEN | | Amirkoushyar Ziabari, Pol Torres, Bjorn Vermeersch, Yi Xuan, Xavier Cartoixà, Alvar Torelló, Je-Hyeong Bahk, Yee Rui Koh, Maryam Parsa, Peide D. Ye, F. Xavier Alvarez & Ali Shakouri | | | When thermal fields in semiconductors approach the submicron scale, non-diffusive heat transport is observed where Fourier based heat transport models fail. Here, the authors use thermal imaging to visualise these thermal field variations and in turn derive a hydrodynamic heat transport model. | | 17 January 2018 | doi: 10.1038/s41467-017-02652-4 | | Condensed-matter physics Imaging techniques Nanoscale devices Nanoscale materials | Phosphorylation induced cochaperone unfolding promotes kinase recruitment and client class-specific Hsp90 phosphorylation OPEN | | Ashleigh B. Bachman, Dimitra Keramisanou, Wanping Xu, Kristin Beebe, Michael A. Moses, M. V. Vasantha Kumar, Geoffrey Gray, Radwan Ebna Noor, Arjan van der Vaart, Len Neckers & Ioannis Gelis | | | The Hsp90 chaperone cycle is influenced by multiple phosphorylation events but their regulatory functions are poorly understood. Here, the authors show that phosphorylation and unfolding of cochaperone Cdc37 tailors the Hsp90 chaperone cycle by recruiting kinases that promote distinct phosphorylation patterns. | | 17 January 2018 | doi: 10.1038/s41467-017-02711-w | | Chaperones Kinases Phosphoproteins Solution-state NMR | Hypoxia-inducible factor-1α is a critical transcription factor for IL-10-producing B cells in autoimmune disease OPEN | | Xianyi Meng, Bettina Grötsch, Yubin Luo, Karl Xaver Knaup, Michael Sean Wiesener, Xiao-Xiang Chen, Jonathan Jantsch, Simon Fillatreau, Georg Schett & Aline Bozec | | | B cells are important for antigen presentation and antibody production in humoral immunity, but are also increasingly recognized for their immune regulatory functions. Here the authors show that HIF-1α, a hypoxia-induced transcription factor, is important for controlling IL-10 induction in and immune-suppressive activity of B cells. | | 17 January 2018 | doi: 10.1038/s41467-017-02683-x | | Autoimmune diseases B-1 cells Gene regulation in immune cells Interleukins | Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels OPEN | | Xia Jiang, Paul F. O’Reilly, Hugues Aschard, Yi-Hsiang Hsu, J. Brent Richards, Josée Dupuis, Erik Ingelsson, David Karasik, Stefan Pilz, Diane Berry, Bryan Kestenbaum, Jusheng Zheng, Jianan Luan, Eleni Sofianopoulou, Elizabeth A. Streeten, Demetrius Albanes, Pamela L. Lutsey, Lu Yao, Weihong Tang, Michael J. Econs et al. | | | Vitamin D deficiency is associated with multiple human pathologic conditions. In a genome-wide association study of 79,366 individuals, Jiang et al. replicate four and identify two new genetic loci for serum levels of 25-hydroxyvitamin D and find evidence for a shared genetic basis with autoimmune diseases. | | 17 January 2018 | doi: 10.1038/s41467-017-02662-2 | | Epidemiology Genetics research Genome-wide association studies Risk factors | Protein phosphatase 5 regulates titin phosphorylation and function at a sarcomere-associated mechanosensor complex in cardiomyocytes OPEN | | Judith Krysiak, Andreas Unger, Lisa Beckendorf, Nazha Hamdani, Marion von Frieling-Salewsky, Margaret M. Redfield, Cris G. dos Remedios, Farah Sheikh, Ulrich Gergs, Peter Boknik & Wolfgang A. Linke | | | Protein phosphatase 5 (PP5) is expressed in many cell types but its role in cardiomyocytes is unknown. Here the authors show that PP5 binds and dephosphorylates elastic titin in cardiac sarcomeres, and that PP5 is increased in heart failure, reducing cardiomyocyte compliance. | | 17 January 2018 | doi: 10.1038/s41467-017-02483-3 | | Heart failure Muscle contraction Phosphorylation | ∆133p53 isoform promotes tumour invasion and metastasis via interleukin-6 activation of JAK-STAT and RhoA-ROCK signalling OPEN | | Hamish Campbell, Nicholas Fleming, Imogen Roth, Sunali Mehta, Anna Wiles, Gail Williams, Claire Vennin, Nikola Arsic, Ashleigh Parkin, Marina Pajic, Fran Munro, Les McNoe, Michael Black, John McCall, Tania L. Slatter, Paul Timpson, Roger Reddel, Pierre Roux, Cristin Print, Margaret A. Baird et al. | | | Aberrant expression of the Δ133p53 isoform is linked to many cancers. Here, the authors utilise a model of the Δ133p53 isoform that is prone to tumours and inflammation, showing that Δ133p53 promotes tumour cell invasion by activation of the JAK-STAT and RhoA-ROCK pathways in an IL-6 dependent manner. | | 17 January 2018 | doi: 10.1038/s41467-017-02408-0 | | Metastasis Tumour-suppressor proteins | Multiplex glycan bead array for high throughput and high content analyses of glycan binding proteins OPEN | | Sharad Purohit, Tiehai Li, Wanyi Guan, Xuezheng Song, Jing Song, Yanna Tian, Lei Li, Ashok Sharma, Boying Dun, David Mysona, Sharad Ghamande, Bunja Rungruang, Richard D. Cummings, Peng George Wang & Jin-Xiong She | | | The low throughput or content of current methods for the analysis of glycans-glycan binding proteins (GBPs) interactions hampers their clinical applications. Here, the authors conjugate synthesized glycans to Luminex beads to detect GBPs and apply it for the discovery of ovarian cancer biomarkers. | | 17 January 2018 | doi: 10.1038/s41467-017-02747-y | | Biomarkers Glycomics High-throughput screening | MAIT cell clonal expansion and TCR repertoire shaping in human volunteers challenged with Salmonella Paratyphi A OPEN | | Lauren J. Howson, Giorgio Napolitani, Dawn Shepherd, Hemza Ghadbane, Prathiba Kurupati, Lorena Preciado-Llanes, Margarida Rei, Hazel C. Dobinson, Malick M. Gibani, Karen Wei Weng Teng, Evan W. Newell, Natacha Veerapen, Gurdyal S. Besra, Andrew J. Pollard & Vincenzo Cerundolo | | | Most MAIT cell response to infection studies are of mice. Here the authors characterize MAIT cell population responses to Salmonella Paratyphi A infection of 25 human volunteers using TCR clonotype analysis and mass cytometry of pre-infection matched to post-infection samples. | | 17 January 2018 | doi: 10.1038/s41467-017-02540-x | | Antimicrobial responses Infection T-cell receptor | Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells OPEN | | Brent D. G. Page, Nicholas C. K. Valerie, Roni H. G. Wright, Olov Wallner, Rebecka Isaksson, Megan Carter, Sean G. Rudd, Olga Loseva, Ann-Sofie Jemth, Ingrid Almlöf, Jofre Font-Mateu, Sabin Llona-Minguez, Pawel Baranczewski, Fredrik Jeppsson, Evert Homan, Helena Almqvist, Hanna Axelsson, Shruti Regmi, Anna-Lena Gustavsson, Thomas Lundbäck et al. | | | NUDIX hydrolases are an important family of nucleotide-metabolizing enzymes. Here, the authors identify potent, small molecule inhibitors of NUDT5, which is implicated in ADP-ribose and 8-oxo-guanine metabolism, and confirm its role in gene regulation and proliferation in breast cancer cells. | | 17 January 2018 | doi: 10.1038/s41467-017-02293-7 | | Breast cancer Drug discovery and development Screening Target validation | The protective role of DOT1L in UV-induced melanomagenesis OPEN | | Bo Zhu, Shuyang Chen, Hongshen Wang, Chengqian Yin, Changpeng Han, Cong Peng, Zhaoqian Liu, Lixin Wan, Xiaoyang Zhang, Jie Zhang, Christine G. Lian, Peilin Ma, Zhi-xiang Xu, Sharon Prince, Tao Wang, Xiumei Gao, Yujiang Shi, Dali Liu, Min Liu, Wenyi Wei et al. | | | The interaction of DOT1L with MLL oncogenic fusion proteins has been implicated in leukemogenesis. Here, the authors show a contrasting role for DOT1L in protecting UVR-induced melanomagenesis by facilitating DNA repair through interaction with XPC. | | 17 January 2018 | doi: 10.1038/s41467-017-02687-7 | | Epigenetics Melanoma | Single-molecule FRET reveals multiscale chromatin dynamics modulated by HP1α OPEN | | Sinan Kilic, Suren Felekyan, Olga Doroshenko, Iuliia Boichenko, Mykola Dimura, Hayk Vardanyan, Louise C. Bryan, Gaurav Arya, Claus A. M. Seidel & Beat Fierz | | | Chromatin fibers undergo continuous structural rearrangements but their dynamic architecture is poorly understood. Here, the authors use single-molecule FRET to determine the structural states and interconversion kinetics of chromatin fibers, monitoring their effector protein-dependent dynamic motions. | | 16 January 2018 | doi: 10.1038/s41467-017-02619-5 | | Chromatin structure Fluorescence resonance energy transfer Kinetics Single-molecule biophysics | Injury-activated glial cells promote wound healing of the adult skin in mice OPEN | | Vadims Parfejevs, Julien Debbache, Olga Shakhova, Simon M. Schaefer, Mareen Glausch, Michael Wegner, Ueli Suter, Una Riekstina, Sabine Werner & Lukas Sommer | | | The peripheral nervous system has been implicated in wound healing. Here, Parfejevs and colleagues report that cutaneous wounding in mice induces the de-differentiation and proliferation of Schwann cells, which disseminate into the wound bed, secrete soluble factors, and promote wound healing. | | 16 January 2018 | doi: 10.1038/s41467-017-01488-2 | | Cell signalling Mechanisms of disease Schwann cell | Granulocyte-colony stimulating factor controls neural and behavioral plasticity in response to cocaine OPEN | | Erin S. Calipari, Arthur Godino, Emily G. Peck, Marine Salery, Nicholas L. Mervosh, Joseph A. Landry, Scott J. Russo, Yasmin L. Hurd, Eric J. Nestler & Drew D. Kiraly | | | Cocaine addiction is accompanied by dysfunction in neural circuits related to reward, but it is unclear how these adaptations occur. Here, authors identify granulocyte-colony stimulating factor as a potent mediator of cocaine-induced adaptations, and show that it can alter the motivation for cocaine. | | 16 January 2018 | doi: 10.1038/s41467-017-01881-x | | Addiction Neuroimmunology | The deep-subsurface sulfate reducer Desulfotomaculum kuznetsovii employs two methanol-degrading pathways OPEN | | Diana Z. Sousa, Michael Visser, Antonie H. van Gelder, Sjef Boeren, Mervin M. Pieterse, Martijn W. H. Pinkse, Peter D. E. M. Verhaert, Carsten Vogt, Steffi Franke, Steffen Kümmel & Alfons J. M. Stams | | | Microorganisms metabolise methanol using either a methanol methyltransferase or a methanol dehydrogenase. Here, the authors use proteomics and stable isotope fractionation to show that a thermophilic sulfate-reducing bacterium, isolated from the deep subsurface, uses both pathways. | | 16 January 2018 | doi: 10.1038/s41467-017-02518-9 | | Bacterial physiology Environmental microbiology | The lncRNA GATA6-AS epigenetically regulates endothelial gene expression via interaction with LOXL2 OPEN | | Philipp Neumann, Nicolas Jaé, Andrea Knau, Simone F. Glaser, Youssef Fouani, Oliver Rossbach, Marcus Krüger, David John, Albrecht Bindereif, Phillip Grote, Reinier A. Boon & Stefanie Dimmeler | | | LncRNAs influence endothelial cell function via a number of mechanisms. Here the authors show that the lncRNA GATA6-AS regulates endothelial gene expression through interaction with the nuclear deaminase LOXL2, with functional consequences on endothelial-mesenchymal transition and angiogenesis. | | 16 January 2018 | doi: 10.1038/s41467-017-02431-1 | | Angiogenesis Histone post-translational modifications Long non-coding RNAs | Dot1 regulates nucleosome dynamics by its inherent histone chaperone activity in yeast OPEN | | Soyun Lee, Seunghee Oh, Kwiwan Jeong, Hyelim Jo, Yoonjung Choi, Hogyu David Seo, Minhoo Kim, Joonho Choe, Chang Seob Kwon & Daeyoup Lee | | | Dot1 is an evolutionarily conserved enzyme, responsible for histone H3K79 methylation in most eukaryotes. Here authors show that, in yeast, Dot1p has histone chaperone activity and regulates nucleosome dynamics via histone exchange in transcribed regions. | | 16 January 2018 | doi: 10.1038/s41467-017-02759-8 | | Chromatin structure Nucleosomes | Cooperating with machines OPEN | | Jacob W. Crandall, Mayada Oudah, Tennom, Fatimah Ishowo-Oloko, Sherief Abdallah, Jean-François Bonnefon, Manuel Cebrian, Azim Shariff, Michael A. Goodrich & Iyad Rahwan | | | Artificial intelligence is now superior to humans in many fully competitive games, such as Chess, Go, and Poker. Here the authors develop a machine-learning algorithm that can cooperate effectively with humans when cooperation is beneficial but nontrivial, something humans are remarkably good at. | | 16 January 2018 | doi: 10.1038/s41467-017-02597-8 | | Computer science Decision making | DNA methyltransferase inhibition upregulates MHC-I to potentiate cytotoxic T lymphocyte responses in breast cancer OPEN | | Na Luo, Mellissa J. Nixon, Paula I. Gonzalez-Ericsson, Violeta Sanchez, Susan R. Opalenik, Huili Li, Cynthia A. Zahnow, Michael L. Nickels, Fei Liu, Mohammed N. Tantawy, Melinda E. Sanders, H. Charles Manning & Justin M. Balko | | | Immunotherapy often fails as a single option treatment in cancer. Here, the authors show that targeting of DNA methyltransferases, such as DNMT1, can potentiate anti-tumor immunity and response to checkpoint inhibition by increasing MHC gene expression and the recruitment of CD8+ T cells. | | 16 January 2018 | doi: 10.1038/s41467-017-02630-w | | Breast cancer Tumour immunology | Fasoracetam in adolescents with ADHD and glutamatergic gene network variants disrupting mGluR neurotransmitter signaling OPEN | | Josephine Elia, Grace Ungal, Charlly Kao, Alexander Ambrosini, Nilsa De Jesus-Rosario, Lene Larsen, Rosetta Chiavacci, Tiancheng Wang, Christine Kurian, Kanani Titchen, Brian Sykes, Sharon Hwang, Bhumi Kumar, Jacqueline Potts, Joshua Davis, Jeffrey Malatack, Emma Slattery, Ganesh Moorthy, Athena Zuppa, Andrew Weller et al. | | | Stimulant drugs are most commonly used to treat ADHD. Here, the authors demonstrate that in adolescents with ADHD who also have genetic variation in genes impacting metabotropic glutamate signaling, the non-stimulant mGluR activator fasoracetam is well tolerated and may be beneficial in alleviating symptoms of this disease. | | 16 January 2018 | doi: 10.1038/s41467-017-02244-2 | | ADHD Genetics Phase I trials | Human caspase-4 detects tetra-acylated LPS and cytosolic Francisella and functions differently from murine caspase-11 OPEN | | Brice Lagrange, Sacha Benaoudia, Pierre Wallet, Flora Magnotti, Angelina Provost, Fanny Michal, Amandine Martin, Flaviana Di Lorenzo, Bénédicte F. Py, Antonio Molinaro & Thomas Henry | | | Lipid A from some bacteria is sensed differently by humans and mice for the activation of the inflammasomes and inflammatory responses, but the mechanisms are not clear. Here, the authors show that murine caspase-11 and human caspase-4/5 contribute to this differential response via their distinct recognition of under-acylated lipid A. | | 16 January 2018 | doi: 10.1038/s41467-017-02682-y | | Antimicrobial responses Infection Inflammasome NOD-like receptors | A bony-crested Jurassic dinosaur with evidence of iridescent plumage highlights complexity in early paravian evolution OPEN | | Dongyu Hu, Julia A. Clarke, Chad M. Eliason, Rui Qiu, Quanguo Li, Matthew D. Shawkey, Cuilin Zhao, Liliana D’Alba, Jinkai Jiang & Xing Xu | | | A number of paravian dinosaurs have been described from the Jurassic Yanliao biota, but these have tended to be morphologically similar to Archaeopteryx. Here, Hu. describe the new paravian dinosaur, Caihong juji gen. et sp. nov., which possesses a suite of unusual skeletal and feather characteristics. | | 15 January 2018 | doi: 10.1038/s41467-017-02515-y | | Palaeontology Taxonomy | Stratospheric ozone loss over the Eurasian continent induced by the polar vortex shift OPEN | | Jiankai Zhang, Wenshou Tian, Fei Xie, Martyn P. Chipperfield, Wuhu Feng, Seok-Woo Son, N. Luke Abraham, Alexander T. Archibald, Slimane Bekki, Neal Butchart, Makoto Deushi, Sandip Dhomse, Yuanyuan Han, Patrick Jöckel, Douglas Kinnison, Ole Kirner, Martine Michou, Olaf Morgenstern, Fiona M. O’Connor, Giovanni Pitari et al. | | | Climate change can exert a significant effect on the ozone recovery. Here, the authors show that the Arctic polar vortex shift associated with Arctic sea-ice loss could slow down ozone recovery over the Eurasian continent. | | 15 January 2018 | doi: 10.1038/s41467-017-02565-2 | | Atmospheric chemistry Climate-change impacts | Elucidating the genomic architecture of Asian EGFR-mutant lung adenocarcinoma through multi-region exome sequencing OPEN | | Rahul Nahar, Weiwei Zhai, Tong Zhang, Angela Takano, Alexis J. Khng, Yin Yeng Lee, Xingliang Liu, Chong Hee Lim, Tina P. T. Koh, Zaw Win Aung, Tony Kiat Hon Lim, Lavanya Veeravalli, Ju Yuan, Audrey S. M. Teo, Cheryl X. Chan, Huay Mei Poh, Ivan M. L. Chua, Audrey Ann Liew, Dawn Ping Xi Lau, Xue Lin Kwang et al. | | | EGFR mutant lung adenocarcinoma (LUAD) exhibit diverse clinical outcomes in response to targeted therapies. Here the authors show that these LUADs involve a complex genomic landscape with high intratumor heterogeneity, providing insights into the evolutionary trajectory of oncogene-driven LUAD and potential mediators of EGFR TKI resistance. | | 15 January 2018 | doi: 10.1038/s41467-017-02584-z | | Cancer genomics Non-small-cell lung cancer | Reconfiguring crystal and electronic structures of MoS2 by substitutional doping OPEN | | Joonki Suh, Teck Leong Tan, Weijie Zhao, Joonsuk Park, Der-Yuh Lin, Tae-Eon Park, Jonghwan Kim, Chenhao Jin, Nihit Saigal, Sandip Ghosh, Zicong Marvin Wong, Yabin Chen, Feng Wang, Wladyslaw Walukiewicz, Goki Eda & Junqiao Wu | | | Substitutional doping is well-established in traditional semiconductors but has not been extensively explored in two-dimensional semiconductors. Here, the authors investigate the structural and electronic effects of Nb doping in MoS2 crystals. | | 15 January 2018 | doi: 10.1038/s41467-017-02631-9 | | Electronic properties and materials Surfaces, interfaces and thin films Two-dimensional materials | Raman enhancement on ultra-clean graphene quantum dots produced by quasi-equilibrium plasma-enhanced chemical vapor deposition OPEN | | Donghua Liu, Xiaosong Chen, Yibin Hu, Tai Sun, Zhibo Song, Yujie Zheng, Yongbin Cao, Zhi Cai, Min Cao, Lan Peng, Yuli Huang, Lei Du, Wuli Yang, Gang Chen, Dapeng Wei, Andrew Thye Shen Wee & Dacheng Wei | | | Surface-enhanced Raman spectroscopy (SERS) is a promising technology for sensitive optical sensors, generally using rough metal films. Here, Liu et al. synthesize high-quality graphene quantum dot films which offer a large SERS enhancement due to a strong light-matter interaction with Van Hove singularities. | | 15 January 2018 | doi: 10.1038/s41467-017-02627-5 | | Raman spectroscopy SERS Synthesis and processing Synthesis of graphene | Experimental quantum simulation of fermion-antifermion scattering via boson exchange in a trapped ion OPEN | | Xiang Zhang, Kuan Zhang, Yangchao Shen, Shuaining Zhang, Jing-Ning Zhang, Man-Hong Yung, Jorge Casanova, Julen S. Pedernales, Lucas Lamata, Enrique Solano & Kihwan Kim | | | Simulation of quantum field theory using quantum systems would in principle allow avoidance of the exponential overhead required for classical simulations. Here, the authors use a multilevel trapped ion to simulate the processes of self-interaction and particle-antiparticle creation/annihilation. | | 15 January 2018 | doi: 10.1038/s41467-017-02507-y | | Quantum optics Quantum simulation Theoretical particle physics | Deubiquitinase USP13 dictates MCL1 stability and sensitivity to BH3 mimetic inhibitors OPEN | | Shengzhe Zhang, Meiying Zhang, Ying Jing, Xia Yin, Pengfei Ma, Zhenfeng Zhang, Xiaojie Wang, Wen Di & Guanglei Zhuang | | | MCL1, a pro-survival BCL-2 related protein with rapid turnover rate, is often dysregulated in cancers. Here, the authors show that MCL1’s stability is regulated by deubiquitinase USP13, and its inhibition sensitises tumor cells to BH3 mimetic inhibitors. | | 15 January 2018 | doi: 10.1038/s41467-017-02693-9 | | Cancer therapy Oncogenes | Escape from thymic deletion and anti-leukemic effects of T cells specific for hematopoietic cell-restricted antigen OPEN | | Ji-Min Ju, Min Ho Jung, Giri Nam, Woojin Kim, Sehwa Oh, Hyun Duk Kim, Joo Young Kim, Jun Chang, Sung Hak Lee, Gyeong Sin Park, Chang-Ki Min, Dong-Sup Lee, Moon Gyo Kim, Kyungho Choi & Eun Young Choi | | | Antigen distribution patterns affect thymic negative selection. Here, the authors show that incomplete thymic negative selection occurs to T cells for hematopoietic cell-restricted antigen H60 in mice, driving graft-versus-leukemia after H60-mismatched bone marrow transplantation. | | 15 January 2018 | doi: 10.1038/s41467-017-02665-z | | Bone marrow transplantation Cytotoxic T cells | Strongly exchange-coupled and surface-state-modulated magnetization dynamics in Bi2Se3/yttrium iron garnet heterostructures OPEN | | Y. T. Fanchiang, K. H. M. Chen, C. C. Tseng, C. C. Chen, C. K. Cheng, S. R. Yang, C. N. Wu, S. F. Lee, M. Hong & J. Kwo | | | Understanding the effects of topological insulators on magnetization dynamics of adjacent magnetic materials is essential for novel spintronic devices. Here, Fanchiang et al. report thickness dependence of interfacial in-plane magnetic anisotropy and damping enhancement in Bi2Se3/yttrium iron garnet (YIG) bilayers, indicating an important role of topological surface states in the magnetization dynamics of YIG. | | 15 January 2018 | doi: 10.1038/s41467-017-02743-2 | | Ferromagnetism Spintronics Topological insulators | Tumor-derived exosomal miR-1247-3p induces cancer-associated fibroblast activation to foster lung metastasis of liver cancer OPEN | | Tian Fang, Hongwei Lv, Guishuai Lv, Ting Li, Changzheng Wang, Qin Han, Lexing Yu, Bo Su, Linna Guo, Shanna Huang, Dan Cao, Liang Tang, Shanhua Tang, Mengchao Wu, Wen Yang & Hongyang Wang | | | How tumor cells control metastatic niche formation is not fully understood. Here, the authors show in a lung metastatic niche, high-metastatic hepatocellular carcinoma cells secrete exosomal miR-1247-3p that leads to activation of β1-integrin-NF-κBsignalling, converting fibroblasts to cancer-associated fibroblasts. | | 15 January 2018 | doi: 10.1038/s41467-017-02583-0 | | Cancer microenvironment Hepatocellular carcinoma | Ligands with 1,10-phenanthroline scaffold for highly regioselective iron-catalyzed alkene hydrosilylation OPEN | | Meng-Yang Hu, Qiao He, Song-Jie Fan, Zi-Chen Wang, Luo-Yan Liu, Yi-Jiang Mu, Qian Peng & Shou-Fei Zhu | | | Hydrosilylation of alkenes poses substantial challenges in terms of regioselectivity. Here, the authors report iron complexes with 1,10-phenantroline ligand scaffolds which display benzylic selectivity in the hydrosilylation of internal alkenes and Markovnikov selectivity with terminal styrenes and 1,3-dienes. | | 15 January 2018 | doi: 10.1038/s41467-017-02472-6 | | Homogeneous catalysis Synthetic chemistry methodology Sustainability | Intelligent image-based in situ single-cell isolation OPEN | | Csilla Brasko, Kevin Smith, Csaba Molnar, Nora Farago, Lili Hegedus, Arpad Balind, Tamas Balassa, Abel Szkalisity, Farkas Sukosd, Katalin Kocsis, Balazs Balint, Lassi Paavolainen, Marton Z. Enyedi, Istvan Nagy, Laszlo G. Puskas, Lajos Haracska, Gabor Tamas & Peter Horvath | | | The isolation of single cells while retaining context is important for quantifying cellular heterogeneity but technically challenging. Here, the authors develop a high-throughput, scalable workflow for microscopy-based single cell isolation using machine-learning, high-throughput microscopy and laser capture microdissection. | | 15 January 2018 | doi: 10.1038/s41467-017-02628-4 | | Image processing Machine learning Optical imaging Single-cell imaging | Causal associations between risk factors and common diseases inferred from GWAS summary data OPEN | | Zhihong Zhu, Zhili Zheng, Futao Zhang, Yang Wu, Maciej Trzaskowski, Robert Maier, Matthew R. Robinson, John J. McGrath, Peter M. Visscher, Naomi R. Wray & Jian Yang | | | Genetic methods are useful to test whether risk factors are causal for or consequence of disease. Here, Zhu et al. develop a generalized summary-based Mendelian Randomization (GSMR) method which uses summary-level data from GWAS to test for causal associations of health risk factors with common diseases. | | 15 January 2018 | doi: 10.1038/s41467-017-02317-2 | | Genome-wide association studies Risk factors Statistical methods | AICDA drives epigenetic heterogeneity and accelerates germinal center-derived lymphomagenesis OPEN | | Matt Teater, Pilar M. Dominguez, David Redmond, Zhengming Chen, Daisuke Ennishi, David W. Scott, Luisa Cimmino, Paola Ghione, Jayanta Chaudhuri, Randy D. Gascoyne, Iannis Aifantis, Giorgio Inghirami, Olivier Elemento, Ari Melnick & Rita Shaknovich | | | In diffuse large B-cell lymphoma (DLBCL) increased epigenetic heterogeneity in the form of cytosine methylation is known to link to a poor clinical outcome. Here, the authors show that AICDA, an enzyme required for DLBCL pathogenesis, increases cytosine methylation heterogeneity. | | 15 January 2018 | doi: 10.1038/s41467-017-02595-w | | B-cell lymphoma Epigenomics | Deregulated PP1α phosphatase activity towards MAPK activation is antagonized by a tumor suppressive failsafe mechanism OPEN | | Ming Chen, Lixin Wan, Jiangwen Zhang, Jinfang Zhang, Lourdes Mendez, John G. Clohessy, Kelsey Berry, Joshua Victor, Qing Yin, Yuan Zhu, Wenyi Wei & Pier Paolo Pandolfi | | | Alterations in the MAPK pathway are common in cancers, yet mutations are rarely found in patients. Here the authors find genomic amplifications of the PPP1CA gene in advanced and metastatic prostate cancer and identify a role for this phosphatase in the positive regulation of ERK signalling. | | 15 January 2018 | doi: 10.1038/s41467-017-02272-y | | Growth factor signalling Prostate cancer | Pixelated spatial gene expression analysis from tissue OPEN | | A. Ganguli, A. Ornob, N. Spegazzini, Y. Liu, G. Damhorst, T. Ghonge, B. Thornton, C. J. Konopka, W. Dobrucki, S. E. Clare, R. Bhargava, A. M. Smith, F. Kosari & R. Bashir | | | Spatial localization of genetic information is important for tissue heterogeneity but difficult to capture with current analytical techniques. Here the authors present “Pixelated RT-LAMP”, an approach that uses parallel on-chip reactions to provide the distribution of target sequences directly from tissue. | | 15 January 2018 | doi: 10.1038/s41467-017-02623-9 | | Biochemical assays Lab-on-a-chip Transcriptomics | Unusual multiscale mechanics of biomimetic nanoparticle hydrogels OPEN | | Yunlong Zhou, Pablo F. Damasceno, Bagganahalli S. Somashekar, Michael Engel, Falin Tian, Jian Zhu, Rui Huang, Kyle Johnson, Carl McIntyre, Kai Sun, Ming Yang, Peter F. Green, Ayyalusamy Ramamoorthy, Sharon C. Glotzer & Nicholas A. Kotov | | | Achieving simultaneous high storage and loss moduli in gels is difficult due to the opposite chemical structure requirements needed for such properties. Here the authors show a spectrum of gels containing CdTe nanoparticles stabilized by glutathione that have such properties which can be rationalised through the developed model. | | 12 January 2018 | doi: 10.1038/s41467-017-02579-w | | Gels and hydrogels Nanoparticles Self-assembly | Engineered nanointerfaces for microfluidic isolation and molecular profiling of tumor-specific extracellular vesicles OPEN | | Eduardo Reátegui, Kristan E. van der Vos, Charles P. Lai, Mahnaz Zeinali, Nadia A. Atai, Berent Aldikacti, Frederick P. Floyd Jr., Aimal H. Khankhel, Vishal Thapar, Fred H. Hochberg, Lecia V. Sequist, Brian V. Nahed, Bob S. Carter, Mehmet Toner, Leonora Balaj, David T. Ting, Xandra O. Breakefield & Shannon L. Stott | | | Extracellular vesicles can carry many different types of biological cargo and have been investigated as a biomarker for cancer diagnosis. Here the authors develop a microfluidic platform for rapid and sensitive isolation of tumor-specific extracellular vesicles. | | 12 January 2018 | doi: 10.1038/s41467-017-02261-1 | | Biomedical engineering Lab-on-a-chip Tumour biomarkers | Carbon-doped SnS2 nanostructure as a high-efficiency solar fuel catalyst under visible light OPEN | | Indrajit Shown, Satyanarayana Samireddi, Yu-Chung Chang, Raghunath Putikam, Po-Han Chang, Amr Sabbah, Fang-Yu Fu, Wei-Fu Chen, Chih-I Wu, Tsyr-Yan Yu, Po-Wen Chung, M. C. Lin, Li-Chyong Chen & Kuei-Hsien Chen | | | Photocatalytic reduction of CO2 to hydrocarbons is a promising route to both CO2 utilization and renewable fuel production. Here the authors identify that carbon-doped SnS2 possesses a high catalytic efficiency towards CO2 reduction owing to low photogenerated charge recombination rates. | | 12 January 2018 | doi: 10.1038/s41467-017-02547-4 | | Nanoscale materials Photocatalysis Solar fuels | NF-κB inducing kinase is a therapeutic target for systemic lupus erythematosus OPEN | | Hans D. Brightbill, Eric Suto, Nicole Blaquiere, Nandhini Ramamoorthi, Swathi Sujatha-Bhaskar, Emily B. Gogol, Georgette M. Castanedo, Benjamin T. Jackson, Youngsu C. Kwon, Susan Haller, Justin Lesch, Karin Bents, Christine Everett, Pawan Bir Kohli, Sandra Linge, Laura Christian, Kathy Barrett, Allan Jaochico, Leonid M. Berezhkovskiy, Peter W. Fan et al. | | | Clinical trials of BAFF blockade with belimumab have shown partial efficacy for the treatment of systemic lupus erythematosus (SLE), so other therapeutic options are required. Here, the authors present a new small molecule inhibitor that targets NIK with a similar efficacy to BAFF inhibition in two mouse models of SLE. | | 12 January 2018 | doi: 10.1038/s41467-017-02672-0 | | Systemic lupus erythematosus Target validation | Fibre-optic metadevice for all-optical signal modulation based on coherent absorption OPEN | | Angelos Xomalis, Iosif Demirtzioglou, Eric Plum, Yongmin Jung, Venkatram Nalla, Cosimo Lacava, Kevin F. MacDonald, Periklis Petropoulos, David J. Richardson & Nikolay I. Zheludev | | | Here, the authors show that integration of metamaterial and optical fibre technologies enables all-optical XOR, NOT and AND logical functions that are performed at up to 40 gigabits per second with few femtojoules per bit energy consumption within a coherent fully fiberized network. | | 12 January 2018 | doi: 10.1038/s41467-017-02434-y | | Fibre optics and optical communications Metamaterials Nanophotonics and plasmonics | CUG initiation and frameshifting enable production of dipeptide repeat proteins from ALS/FTD C9ORF72 transcripts OPEN | | Ricardos Tabet, Laure Schaeffer, Fernande Freyermuth, Melanie Jambeau, Michael Workman, Chao-Zong Lee, Chun-Chia Lin, Jie Jiang, Karen Jansen-West, Hussein Abou-Hamdan, Laurent Désaubry, Tania Gendron, Leonard Petrucelli, Franck Martin & Clotilde Lagier-Tourenne | | | Repeat-associated non-AUG (RAN) translation contributes to the pathogenic mechanism of several microsatellite expansion diseases. Here the authors delineate the different steps involved in recruiting the ribosome to initiate G4C2 RAN translation to produce poly-Glycine Alanine, poly-Glycine Proline, and poly-Glycine Arginine repeats. | | 11 January 2018 | doi: 10.1038/s41467-017-02643-5 | | Amyotrophic lateral sclerosis Dementia Ribosome | Signaling ammonium across membranes through an ammonium sensor histidine kinase OPEN | | Tobias Pflüger, Camila F. Hernández, Philipp Lewe, Fabian Frank, Haydyn Mertens, Dmitri Svergun, Manfred W. Baumstark, Vladimir Y. Lunin, Mike S. M. Jetten & Susana L. A. Andrade | | | For anammox bacteria, the sensing and uptake of ammonium is essential and specialized proteins, like Ks-Amt5, mediate such processes. Here, authors perform biophysical, biochemical, and structural analysis on Ks-Amt5 and establish a role for this protein as an ammonium-sensing signal transducer. | | 11 January 2018 | doi: 10.1038/s41467-017-02637-3 | | Ion transport Permeation and transport X-ray crystallography | MXene molecular sieving membranes for highly efficient gas separation OPEN | | Li Ding, Yanying Wei, Libo Li, Tao Zhang, Haihui Wang, Jian Xue, Liang-Xin Ding, Suqing Wang, Jürgen Caro & Yury Gogotsi | | | Two-dimensional materials show great potential for membrane technologies, but their disordered channels hinder their molecular sieving performance. Here, Wang, Gogotsi and colleagues design a MXene membrane with ordered nanochannels that exhibits an excellent H2/CO2 gas separation performance. | | 11 January 2018 | doi: 10.1038/s41467-017-02529-6 | | Chemical engineering Materials chemistry Porous materials Two-dimensional materials | Impaired autophagy bridges lysosomal storage disease and epithelial dysfunction in the kidney OPEN | | Beatrice Paola Festa, Zhiyong Chen, Marine Berquez, Huguette Debaix, Natsuko Tokonami, Jenny Ann Prange, Glenn van de Hoek, Cremonesi Alessio, Andrea Raimondi, Nathalie Nevo, Rachel H. Giles, Olivier Devuyst & Alessandro Luciani | | | Nephropathic cystinosis is a lysosomal storage disease characterized by proximal tubular cell dysfunction. Here Festa and colleagues show that these lysosomal alterations lead to defective autophagic clearance of mitochondria and increased oxidative stress that, in turn, activates the transcription factor ZONAB leading to impaired cell differentiation. | | 11 January 2018 | doi: 10.1038/s41467-017-02536-7 | | Fanconi syndrome Lysosomes Macroautophagy Mechanisms of disease | | | | | | | | Advertisement | | Do you have a career question? The Naturejobs podcast features one-on-one Q&As, panel discussions and other exclusive content to help scientists with their careers. Hosted on the Naturejobs blog, the podcast is also available on iTunes and Soundcloud. Listen today! | | | | | | Advertisement | | | | | Advertisement | | | | | | | | | | | Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. 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